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examples of mechanistic modelsinclude the early “one-hit” and the subsequent “multi-hit” models for carcinogenesis. At puberty, these cords become canalized, and thegonocytes begin the multiple divisions that give rise to the spermatogonia that, in turn, will divide and differentiate into the maturesperm. At the edges ofthe portal canal, between the connective tissue stroma andthe hepatocytes, is a small space called the periportal space(space of Mall) At the edges ofthe portal canal, between the connective tissue stroma andthe hepatocytes, is a small space called the periportal space(space of Mall). Coughstrength was measured subjectively and objec-tively by measuring a patient’s ability to propelsecretions onto a card placed 1–2 cm away fromthe endotracheal tube. However, the Cx43 configuration exhibited the widest range of conductanceswhen compared to either Cx40 or Cx26.
res-cue HFOV) in infants with respiratory distresssyndrome given the more recent understandingthat “non-lung-protective” mechanical ventila-tion, large tidal volume ventilation and/or highpeak pressure ventilation or probably more highpeak to PEEP pressure swings can cause orworsen lung injury in the experimental settingwithin a short time period (Bjorklund et al. As mentioned previously, this apoptoticpathway will be discussed in detail in the second half of this chapter.
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